Clinical Tools & Calculators

Levetiracetam (Keppra) – Loading Dose

For educational use. This tool is intended for reference and education. All care decisions require a direct clinical assessment of the patient and independent verification of doses and values by the treating team. The calculation runs locally in your browser, no patient data is sent to any server.

Levetiracetam (Keppra) – Loading Dose

An alternative anticonvulsant to phenytoin, with a better safety profile, fewer drug interactions, and no need for routine level monitoring. It is increasingly preferred for post-operative prophylaxis and for status epilepticus.

1200
mg
Infuse IV over 15 minutes
Clinical notes:
  • Maintenance: 20–60 mg/kg/day divided q12h (max 3000 mg/day adult).
  • Renal dose adjustment required for CrCl < 80 mL/min.
  • Monitor behavioural changes – irritability, aggression, depression are common.
  • Can be given PO or IV at the same dose (100% bioavailability).

Reference: Kapur J, et al. (ESETT Group). Randomized trial of three anticonvulsant medications for status epilepticus. N Engl J Med 2019;381(22):2103–2113. PMID 31774955 · doi:10.1056/NEJMoa1905795

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